Clinical Evidence

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

Autologous Protein Solution Injections for the Treatment of Knee Osteoarthritis. 3-Year Results.

Abstract Background: Blood derivative injections have been recently proposed to address osteoarthritis (OA) with overall positive results, although long-term data on their efficacy are lacking. A novel blood derivative has…

Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months

The Regenerative Clinic’s view on this research

Mr Nima Heidari: Here at The Regenerative Clinic, we have been treating patients with knee arthritis with micro-fragmented fat for two and a half years.  We have collected data diligently on all of our patients in order to keep a very close eye on the improvements that they have following our treatment.  We have now collated and analysed this data for a group of our patients with knee arthritis.  We have looked at the group with moderate-to-severe arthritis where their pain is graded above 50 on the visual analogue scale.  The visual analogue scale is such that 0 is no pain at all and 100 represents pain where the patient needs to access emergency care due to this pain.  We have found consistently across various patient reported outcome measures that there is an improvement in the majority of patients who are treated this way.  4/5 patients treated see an improvement in their symptoms at one year.  Interestingly, we have also noted that there are very few complications and adverse events associated with this treatment.  The most common being discomfort at the site where the fat is usually harvested around the abdomen.

Although not all of our patients have had improvements in the symptoms with 1/5 not deriving a great deal of benefit, 4/5 are glad that they have undertaken the treatment and have seen improvements in their pain and function.

Abstract Introduction. Microfragmented adipose tissue (MFAT) has been shown to benefit osteoarthritic patients by reducing pain and supporting tissue regeneration through a mesenchymal stem cell (MSC)-related paracrine mech…

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

Abstract Monocytes and macrophages play a critical role in tissue development, homeostasis, and injury repair. These innate immune cells participate in guiding vascular remodeling, stimulation of local stem and progenitor …

Elevated Monocytes in Patients with Critical Limb Ischemia Diminish after Bypass Surgery

Abstract  Mononuclear cells (MNC) increase neovascularization and ulcer healing after injection into an ischemic extremity. Circulating MNC are composed of lymphocytes (85%), monocytes (15%) and endothelial progenitor c…

Synovial Tissue Macrophages: Friend or Foe?

Abstract Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into pro-infl…

Macrophage Cell Lines Produce Osteoinductive Signals That Include Bone Morphogenetic protein-2

Abstract Bone wound healing requires osteoinductive signals that are attributed to (the) bone morphogenetic proteins (BMPs). The cellular origin of such osteoinductive signals has only been partially elucidated. Because of…

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury

Abstract CC chemokine receptor 2 (CCR2) is essential to acute skeletal muscle injury repair. We studied the subpopulation of inflammatory cells recruited via CCR2 signaling and their cellular functions with respect to mu…

Changes in Macrophage Phenotype and Induction of Epithelial-To-Mesenchymal Transition Genes Following Acute Achilles Tenotomy and Repair

Abstract Tendon injuries occur frequently in physically active individuals, but the clinical outcomes for these injuries can be poor. In many injured tissues the repair process is orchestrated by two types of cells, macropha…

Micro Fragmented Adipose Tissue Promotes the Matrix Synthesis Function of Nucleus Pulposus Cells and Regenerates Degenerated Intervertebral Disc in a Pig Model

Abstract Intervertebral disc (IVD) degeneration and consequent lower back pain is a common disease. Micro fragmented adipose tissue (MFAT) is promising for a wide range of applications in regenerative medicine. In this stu…

Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis

Abstract This study aimed to determine whether autologous orthobiologic tissue source affects pain and functional outcomes in patients with symptomatic knee osteoarthritis (OA) who received microfragmented adipose tissue …

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