Clinical Evidence

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

To see how the treatment could help you make an appointment our multidisciplinary team or call 0330 2233332 for more information.

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

The Regenerative Clinic’s view on this research

This paper published in December 2019, reports on patients with advanced knee arthritis treated with Micro-fragmented Fat. The patients were monitored over a 24-month period. Their pain and function were recorded; and all had an MRI scan immediately before the treatment and 24 months after.

17 patients were enrolled and 10 fulfilled the criteria for follow-up. Three had a joint replacement and 4 were lost to follow-up. All of the 10 patients followed-up at 24 months showed a significant reduction in pain and an overall notable increase in the volume of cartilage measured on the contrast-enhanced MRI scan.

This study demonstrates a degree of regeneration of the cartilage which is associated with pain relief in a significant proportion of patients who had a single injection of micro-fragmented fat for knee arthritis.

Abstract Osteoarthritis (OA) is a widely prevalent disease worldwide, and with an increasingly ageing society, it has become a challenge for the field of regenerative medicine. OA is a disease process involving multiple j…

Cell therapy versus simultaneous contralateral decompression in symptomatic corticosteroid osteonecrosis: a thirty year follow-up prospective randomized study of one hundred and twenty five adult patients

The Regenerative Clinic’s view on this research

Mr Ali Noorani “A further study in hip arthritis with femoral head osteonecrosis was published in 2018. The study included a total of 125 patient in bilateral hip osteonecrosis. The results are very interesting, this was a 30 year follow up of perspective randomised study of a large number of patients. These patients who had bilateral osteonecrosis i.e both hips are affected, the larger lesions were treated with BMAC and the smaller lesions were treated with just decompression. Overall, the results of bone marrow were clearly superior. Only 28% of the bone marrow group collapsed compared to 72% of the decompression group. In addition, only 24% of the patients had total hip replacement compared to 76% of just the decompression group.”

Abstract PURPOSE: Symptomatic osteonecrosis related to corticosteroids has a high risk of progression to collapse in absence of treatment. The purposes of this study were to evaluate the results of autologous bone marrow…

Role of Inflammation and the Immune System in the Progression of Osteoarthritis

Abstract Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide future therapeutic strategies to modulate the disease progression. The current paradigm of OA is evolving from a purely m…

Autologous Interleukin 1 Receptor Antagonist Blood-Derived Products for Knee Osteoarthritis: A Systematic Review.

Abstract PURPOSE: To systematically review the available clinical data regarding the use of autologous IL-1 receptor antagonist blood products (AILBPs) and their validity as an alternative intra-articular (IA) therapy fo…

Innovative regenerative medicine in the management of knee OA: The role of Autologous Protein Solution

Abstract Osteoarthritis (OA) is one of the most common causes of chronic disability in adults due to pain and altered joint function. Although most patients report pain and functional limitation, symptoms, age of onset a…

Role of White Blood Cells in Blood- and Bone Marrow-Based Autologous Therapies

Abstract There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions in the practice of biologic o…

Autologous protein solution as a therapy for middle-aged females with patellofemoral osteoarthritis: a 12-month clinical study

Abstract Purpose: Symptomatic patellofemoral osteoarthritis (OA) is twice as common in females than males above the age of 30 and appears to be resistant to most injection therapies. The purpose of this trial is to determi…

Duration effects of a single intra-articular injection of Autologous Protein Solution (APS) in patients with knee osteoarthritis (OA)

Abstract Purpose: Autologous anti-inflammatories (AAI) are a class of blood-derived products with high concentrations of anti-inflammatory cytokines that are currently being investigated for the treatment of mild to modera…

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

Abstract BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists …

An Autologous Anti- Inflammatory Protein Solution Yielded a Favorable Safety Profile and Significant Pain Relief in an Open-Label Pilot Study of Patients with Osteoarthritis

Abstract Osteoarthritis (OA) is a progressive and degenerative disease, which may result in significant pain and decreased quality of life. Recent updates in our understanding of OA have demonstrated that it is a whole j…

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