Clinical Evidence

We are happy to announce we have four published papers based on data from patients we have treated at The Regenerative Clinic. Our most recent is a paper on the use of MFAT and PRP to treat hip osteoarthritis which you can read here.

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

To see how the treatment could help you make an appointment our multidisciplinary team or call 0330 2233332 for more information.



Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

Characterization of Microfragmented Adipose Tissue Architecture, Mesenchymal Stromal Cell Content and Release of Paracrine Mediators

Abstract: The use of microfragmented adipose tissue ( FAT) for the treatment of musculoskeletal disorders, especially osteoarthritis (OA), is gaining popularity, following positive results reported in recent case series and…

Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year

Hip osteoarthritis (OA) is a major contributor to reduced quality of life and concomitant disability associated with lost working life months. Intra-articular injection of various biological materials has shown promise in all…

Micro-fragmented adipose tissue regulated the biological functions of osteoarthritis synoviocytes by upregulating MiR-92a-3p expression

Abstract Apart from the treatment potential of micro-fragmented adipose tissue (MF) in joint diseases, what’s less clear is the mechanism of MF on Osteoarthritis (OA). Synoviocytes isolated from synovium tissues of 11 kn…

Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Comparative Study

Abstract Purpose: To compare a single abdominal microfat (MF) injection mixed or not with platelet-rich plasma (PRP) Low Dose (LD) or High Dose (HD) in order to improve MRI parameters, alleviate pain and enhance funct…

Safety and Feasibility of Autologous Micro-Fragmented Adipose Tissue Injections for the Treatment of Vaginal Atrophy, Vulvovaginal Dystrophy, and Stress Urinary Incontinence: An Observational Case Series

Abstract  Objective: Vaginal atrophy, vulvovaginal dystrophy, and stress urinary incontinence (SUI), common conditions in women, have detrimental effects on quality of life. Current treatments require ongoing use and are as…

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years

In this work, Heidari et al, analysed the 24-month outcome from a cohort of 344 patients, suffering from grade 3-4 (moderate to severe) knee osteoarthritis, [many of whom were on the waiting list for total knee replacement], …

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Abstract Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, …

Characterisation of Novel Angiogenic and Potent Anti-Inflammatory Effects of Micro-Fragmented Adipose Tissue

In this work, the authors performed a detailed in vitro characterization of the biological properties of micro-fragmented adipose tissue (MFAT) obtained from eight volunteers who underwent liposuction and provided material ge…

A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury

In this single group pilot study, a series of  10 wheel-chair users with chronic moderate-to severe shoulder pain caused by refractory rotator cuff disease received an ultra-sound guided intra-articular injection of Lipogems…

The regeneration of damaged connective tissue: wishful thinking or reality?

This review provides a clinical and biological analysis/overview of publications that have identified injectable therapeutics including mesenchymal stem cells (MSCs), platelet-rich plasma (PrP) and Gold-induced cytokines (GOL…

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