Clinical Evidence

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

To see how the treatment could help you make an appointment our multidisciplinary team or call 0330 2233332 for more information.

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

The Regenerative Clinic’s view on this research

This paper published in December 2019, reports on patients with advanced knee arthritis treated with Micro-fragmented Fat. The patients were monitored over a 24-month period. Their pain and function were recorded; and all had an MRI scan immediately before the treatment and 24 months after.

17 patients were enrolled and 10 fulfilled the criteria for follow-up. Three had a joint replacement and 4 were lost to follow-up. All of the 10 patients followed-up at 24 months showed a significant reduction in pain and an overall notable increase in the volume of cartilage measured on the contrast-enhanced MRI scan.

This study demonstrates a degree of regeneration of the cartilage which is associated with pain relief in a significant proportion of patients who had a single injection of micro-fragmented fat for knee arthritis.

Abstract Osteoarthritis (OA) is a widely prevalent disease worldwide, and with an increasingly ageing society, it has become a challenge for the field of regenerative medicine. OA is a disease process involving multiple j…

Cell therapy versus simultaneous contralateral decompression in symptomatic corticosteroid osteonecrosis: a thirty year follow-up prospective randomized study of one hundred and twenty five adult patients

The Regenerative Clinic’s view on this research

Mr Ali Noorani “A further study in hip arthritis with femoral head osteonecrosis was published in 2018. The study included a total of 125 patient in bilateral hip osteonecrosis. The results are very interesting, this was a 30 year follow up of perspective randomised study of a large number of patients. These patients who had bilateral osteonecrosis i.e both hips are affected, the larger lesions were treated with BMAC and the smaller lesions were treated with just decompression. Overall, the results of bone marrow were clearly superior. Only 28% of the bone marrow group collapsed compared to 72% of the decompression group. In addition, only 24% of the patients had total hip replacement compared to 76% of just the decompression group.”

Abstract PURPOSE: Symptomatic osteonecrosis related to corticosteroids has a high risk of progression to collapse in absence of treatment. The purposes of this study were to evaluate the results of autologous bone marrow…

Safety and Treatment Effectiveness of a Single Autologous Protein Solution Injection in Patients with Knee Osteoarthritis

Abstract Osteoarthritis (OA) is a common degenerative condition characterized by pain and loss of function. A pathological biochemical environment with excess inflammatory and catabolic proteins is a major contributor to OA….

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

Abstract BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists …

Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses

Abstract Objective: To evaluate intra-articular autologous protein solution (APS) for the treatment of osteoarthritis in horses. Animals: 40 client-owned horses with naturally occuring osteoarthritis. Procedures: APS was…

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

Abstract Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to d…

Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: a randomized controlled single-center clinical trial (MiFrAADiF)

Abstract Background: The diabetic foot ulcer (DFU) is one of the most prevalent complications of diabetes mellitus and often develops severe effects that can lead to amputation. A non-healing “minor” amputation o…

Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study

Abstract Aim: To analyze clinical and functional effects of intra-articular injection of autologous micro-fragmented lipoaspirate (MLA) in patients with late stage knee osteoarthritis (KOA). Secondary aims included clas…

Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart

Abstract Osteoarthritis (OA) is a degenerative joint disease accompanied by pain and loss of function. Adipose tissue harbors mesenchymal stem/stromal cells (MSC), or medicinal signaling cells as suggested by Caplan (Capla…

Use of adipose tissue stem cells in chronic skin lesions: clinical experience

Abstract The healing of a chronic wound is an articulated and complex process, requiring a patient’s clinical global vision. However, local treatment of the wound bed is of fundamental importance. More and more now we t…

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