Clinical Evidence

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

To see how the treatment could help you make an appointment our multidisciplinary team or call 0330 2233332 for more information. Read our recently published article about the success of treating knee OA with microfragmented fat in the highly prestigious journal Stem Cell International.

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

Intra-Articular Injection of Autologous Microfat and Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Comparative Study

Abstract Purpose: To compare a single abdominal microfat (MF) injection mixed or not with platelet-rich plasma (PRP) Low Dose (LD) or High Dose (HD) in order to improve MRI parameters, alleviate pain and enhance funct…

Safety and Feasibility of Autologous Micro-Fragmented Adipose Tissue Injections for the Treatment of Vaginal Atrophy, Vulvovaginal Dystrophy, and Stress Urinary Incontinence: An Observational Case Series

Abstract  Objective: Vaginal atrophy, vulvovaginal dystrophy, and stress urinary incontinence (SUI), common conditions in women, have detrimental effects on quality of life. Current treatments require ongoing use and are as…

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years

In this work, Heidari et al, analysed the 24-month outcome from a cohort of 344 patients, suffering from grade 3-4 (moderate to severe) knee osteoarthritis, [many of whom were on the waiting list for total knee replacement], …

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Abstract Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, …

Characterisation of Novel Angiogenic and Potent Anti-Inflammatory Effects of Micro-Fragmented Adipose Tissue

In this work, the authors performed a detailed in vitro characterization of the biological properties of micro-fragmented adipose tissue (MFAT) obtained from eight volunteers who underwent liposuction and provided material ge…

A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury

In this single group pilot study, a series of  10 wheel-chair users with chronic moderate-to severe shoulder pain caused by refractory rotator cuff disease received an ultra-sound guided intra-articular injection of Lipogems…

The regeneration of damaged connective tissue: wishful thinking or reality?

This review provides a clinical and biological analysis/overview of publications that have identified injectable therapeutics including mesenchymal stem cells (MSCs), platelet-rich plasma (PrP) and Gold-induced cytokines (GOL…

Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue

This case history describes a 56 years old male patient with previous below knee amputation, who suffered a chronic (over three years) non-healing residual limb ulcer following total knee replacement. The patient was treated …

Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a multi-centric, international study

Abstract The aim of this study is to evaluate the outcomes of autologous microfragmented adipose tissue (MFAT) injection in elderly patients with knee osteoarthritis (OA). We hypothesized that MFAT knee infiltration for th…

Refractory Complex Crohn’s Perianal Fistulas: A Role for Autologous Microfragmented Adipose Tissue Injection

Background: Complex perianal fistulas represent one of the most challenging manifestations of Crohn’s disease. Combined surgical and medical therapy with biologic drugs today represent the first-line treatment option, bu…

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