Clinical Evidence

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information.

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

Read the full clinical paper

Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.

Clinical Papers

Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a multi-centric, international study

Abstract The aim of this study is to evaluate the outcomes of autologous microfragmented adipose tissue (MFAT) injection in elderly patients with knee osteoarthritis (OA). We hypothesized that MFAT knee infiltration for th…

Refractory Complex Crohn’s Perianal Fistulas: A Role for Autologous Microfragmented Adipose Tissue Injection

Background: Complex perianal fistulas represent one of the most challenging manifestations of Crohn’s disease. Combined surgical and medical therapy with biologic drugs today represent the first-line treatment option, bu…

Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: a prospective case-control study

Background Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 years…

Preliminary Study on the Echo-Assisted Intersphincteric Autologous Microfragmented Adipose Tissue Injection to Control Fecal Incontinence in Children Operated for Anorectal Malformations

Aim of the study: To assess the efficacy of a novel technique (echo-assisted intersphincteric autologous microfragmented adipose tissue injection, also called “anal-lipofilling”) in the management of non-responsive fecal inco…

Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years

Abstract Knee osteoarthritis is a major cause of disability worldwide. Newer modalities of treatment with less morbidity, such as intra-articular injection of microfragmented fat (MFAT), are showing promise. We report on o…

Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study

The Regenerative Clinic’s view on this research

Professor Mark Slevin: The work describes a pilot clinical trial investigating the utility of autologous liposucted, Lipogems-derived MFAT for treatment of knee pain caused by mild to moderate osteoarthritis from original mostly complex meniscal tears in 20 patients (mean age 59 years) who had failed in initial alternative conservative management. The individuals were treated with ultrasound-guided intra-meniscal articular MFAT injections. Follow up was provided by measurement of the NPS (pain) and KOOS (outcome scale) after 3, 6 and 12 months. Results showed a significant reduction in pain (NPS mean 5.4 to 2.2) and increase in KOOS (mean 58 to 78) by 3 months and this remained constant up to the 12-month test period. The authors suggest MFAT treatment could be an effective and safe treatment for degenerative osteoarthritis and meniscal tears and that a large randomized controlled clinical trial is warranted.

Abstract Purpose: The management of knee pain secondary to meniscal tears with osteoarthritis is limited by the poor inherent healing potential of the meniscus. Previous studies have reported on the benefit of autologous …

Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs)

The Regenerative Clinic’s view on this research

Professor Mark Slevin: This review provides a thorough investigation of the literature surrounding the potential utilization of mesenchymal stem cells (MSCs) for therapeutic application for cell and tissue repair, replacement and regeneration. In particular, it describes and compares the sources of these MSCS i.e. derivation from adipose tissue (ADSCs), bone marrow (BM-MSCs) and umbilical cord (UC-MSCs). The authors summarized that all sources of MSCs possessed similar anti-inflammatory properties through secretion of proteins such as IL-1R-alpha antagonist, although ADSCs had the greatest level of secretion of these factors and secreted more proteins with higher gene activity than MSCs from other sources.

The harvesting of these cells ranges from the most simple-UC-MSCs at birth through liposucted ADSCs to the most invasive and painful procedure for the removal of BM-MSCs. BM-MSCs constitute only around 0.002% of the total cell population, their isolation is variable and the maximum number of divisions (for expansion and storage or use) is limited to around 12 passages. All sources of MSCs are multi-potent, that is that they can differentiate into adipogenic, chondrogenic or osteogenic precursors, however, the potential of BM-MSCs to differentiate decreases with age as does their number and life span. UC-MSCs generally maintain there multipotency for longer, have higher potency of osteogenic differentiation and also express embryonic stem cell markers-that have translated into their experimental use for treatment of neurological disease following differentiation into spinal cord tissue etc. ADSCs present at around 2% of the stromal cell fraction (making it much easier to culture up required numbers for treatment or strorage) maintaining their differentiation capacity in aged subjects and with almost zero expression of HLADR, are suitable for allogeneic transplantation. In addition, they also possess multi-potency giving them the potential to be used beyond mesodermal regenerative and reparative applications.

In a summary of current use, the authors indicate the advantages in safety and efficacy of ADSCs when compared to other sources of MSCs, in regard to clinical studies involving wound healing, stroke, brain and spinal cord injury, autoimmune disorders such as Lupus, osteoarthritis     

concerning bone and cartilage repair and regeneration, and cardiovascular disease such as myocardial tissue repair.

Abstract Adipose tissue is now on the top one of stem cell sources regarding its accessibility, abundance, and less painful collection procedure when compared to other sources. The adipose derived stem cells (ADSCs) that it …

Autologous Protein Solution Injections for the Treatment of Knee Osteoarthritis. 3-Year Results.

Abstract Background: Blood derivative injections have been recently proposed to address osteoarthritis (OA) with overall positive results, although long-term data on their efficacy are lacking. A novel blood derivative has…

Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months

The Regenerative Clinic’s view on this research

Mr Nima Heidari: Here at The Regenerative Clinic, we have been treating patients with knee arthritis with micro-fragmented fat for two and a half years.  We have collected data diligently on all of our patients in order to keep a very close eye on the improvements that they have following our treatment.  We have now collated and analysed this data for a group of our patients with knee arthritis.  We have looked at the group with moderate-to-severe arthritis where their pain is graded above 50 on the visual analogue scale.  The visual analogue scale is such that 0 is no pain at all and 100 represents pain where the patient needs to access emergency care due to this pain.  We have found consistently across various patient reported outcome measures that there is an improvement in the majority of patients who are treated this way.  4/5 patients treated see an improvement in their symptoms at one year.  Interestingly, we have also noted that there are very few complications and adverse events associated with this treatment.  The most common being discomfort at the site where the fat is usually harvested around the abdomen.

Although not all of our patients have had improvements in the symptoms with 1/5 not deriving a great deal of benefit, 4/5 are glad that they have undertaken the treatment and have seen improvements in their pain and function.

Abstract Introduction. Microfragmented adipose tissue (MFAT) has been shown to benefit osteoarthritic patients by reducing pain and supporting tissue regeneration through a mesenchymal stem cell (MSC)-related paracrine mech…

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

Abstract Monocytes and macrophages play a critical role in tissue development, homeostasis, and injury repair. These innate immune cells participate in guiding vascular remodeling, stimulation of local stem and progenitor …

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