Comparison of the Effect of MFAT and MFAT + PRP on Treatment of Hip Osteoarthritis: An Observational, Intention-to-Treat Study at One Year

Hip osteoarthritis (OA) is a major contributor to reduced quality of life and concomitant disability associated with lost working life months. Intra-articular injection of various biological materials has shown promise in alleviating symptoms and potentially slowing down the degenerative process. Here, we compared the effects of treatment of a cohort of 147 patients suffering from grade 1–4 hip OA; with either micro-fragmented adipose tissue (MFAT), or a combination of MFAT with platelet-rich plasma (PRP). We found significant improvements in both the visual analogue score for pain (VAS) and Oxford hip score (OHS) that were similar for both treatments with over 60% having an improvement in the VAS score of 20 points or more. These results suggest a positive role for intra-articular injection of MFAT + PRP as a treatment for hip osteoarthritis which may be important particularly in low body mass index (BMI) patients where the difficulty in obtaining sufficient MFAT for treatment could be offset by using this combination of biologicals.

Conclusions
In this first of its kind clinical study, we have shown the efficacy of MFAT and combinational preparation in successful amelioration of hip pain together with improved joint function in patients treated with OA. Both MFAT and MFAT + PRP intra-articular injections were equally effective in improving VAS and OHS scores over 6–12 months. A larger clinical trial is warranted in order to characterize in detail the effectiveness in patients with different grades of OA, to determine long-term benefits over 2–5 years, and any gender-related differences in response.
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