Clinical Evidence PRP

PRP therapy is an effective and well researched treatment. It has been widely used in sport injuries as well as in aesthetic medicine. To find out more, please see the clinical evidence below.

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Dr. Mikel Sánchez PRP study

Dr. Mikel Sánchez explains how his recent study supports the safety and efficacy of PRP for pain relief and improved function in patients with osteoarthritis in the hip.

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To narrow your search please select an area of below to read the latest research. 

Clinical Papers- Intraosseous PRP

Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis (Sánchez 2016)
Prof. Wilson (The Regenerative Clinic) “This is a great paper from my good friend Mikel Sanchez the godfather of PRP from Victoria in northern Spain. He really has been at the heart of PRP since it’s inception 20 years ago. He shown as have many of the randomise control studies that PRP works extremely well in grade 1 and grade 2 and even moderately advanced grade 3 osteoarthritis but is not effective in grade 4. This novel treatment involves injecting the PRP into the ends of the bone using a small metal needle. The bone itself is a little bit like a Crunchy bar and is easy to inject and by injecting the bone with treating the inflammatory mediators of arthritis located within the subchondral bone or bone just beneath the surface of the joint. Using interosseous PRP he shows that grade for osteoarthritis can be treated effectively in this excellent paper”.

Intraosseous injection of Platelet Rich Plasma for the treatment of severe knee osteoarthritis: a case-control study (Pompei) These results provide useful information about the clinical efficacy of intraosseous infiltrations of PRP in patients with severe knee osteoarthritis, and open new perspectives on additionally targeting subchondral bone to treat knee osteoarthritis.

Treating Severe Knee Osteoarthritis with Combination of Intra-Osseous and Intra-Articular Infiltrations of Platelet-Rich Plasma (Sánchez 2018)
Combination of intra-articular and intra-osseous infiltrations of PRP was not clinically superior at 2 months, but it showed superior clinical outcomes at 6 and 12 months when compared with intra-articular injections of PRP.

Intraosseous Infiltration of Platelet-Rich Plasma for Severe Hip Osteoarthritis (Fiz 2017) This work describes a technique of platelet-rich plasma (PRP) infiltration for the treatment of severe hip osteoarthritis (OA).

Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip (Guadilla 2012)
Arthroscopic management of avascular necrosis of the femoral head is viable and has significant advantages. Clinical studies should justify the theoretical additional benefits of this approach. 

Clinical Papers-PRP therapy for the Spine

Intradiscal and intra-articular facet injections using PRP Intradiscal and intra-articular facet infiltrations with ‘Endoret’ plasma rich in growth factors reduce pain in patients with chronic low back pain

Clinical Papers-PRP therapy for Achilles Tendinopathy

Platelet-rich plasma injections for the treatment of refractory Achilles tendinopathy (Filardo 2014) Chronic Achilles tendinopathy is responsible for a severe reduction in physical performance and persistent pain.

Bilateral traumatic rupture of Achilles tendons in absence of risk factors treated with percutaneous technique and platelet-rich plasma (Guelfi 2014)
We present a clinical case of a 52-year-old man with bilateral traumatic rupture of the Achilles tendon
(AT) in absence of risk factors.

Effect of High-Volume Injection (Boesen 2017)
Effect of High-Volume Injection, PlateletRich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy

A Prospective Series of Patients with Chronic Achilles Tendinopathy (Deans 2012) A Prospective Series of Patients with Chronic Achilles Tendinopathy Treated with Autologous-conditioned Plasma Injections Combined with Exercise and Therapeutic Ultrasonography

Clinical Papers-PRP therapy for tennis/golfers elbow (epicondylitis)

Autologous Proliferative Therapies in Recalcitrant Epicondylitis (Tetschke 2014)
This study investigates the clinical effects of autologous conditioned plasma (ACP) injections and low-level laser application as therapy options for chronic lateral epicondylitis.

Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial (Peerbooms 2010)
To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis.

Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis (Gosens 2011) This trial was undertaken to determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis with a 2-year follow-up.

Platelet-Rich Plasma Significantly Improves Clinical Outcomes in Patients With Chronic Tennis Elbow (Mishra 2013)
To evaluate the clinical value of tendon needling with PRP in patients with chronic tennis elbow compared with an active control group.

Leukocyte-poor platelet-rich plasma versus bupivacaine for recalcitrant lateral epicondylar tendinopathy (Behera 2015)
To compare a single leukocyte-poor (type-4B) platelet-rich plasma (PRP) injection versus bupivacaine injection for recalcitrant lateral epicondylar tendinopathy (LET).

A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery (Ford A 2015)
The aim of this study is to compare the outcomes of platelet-rich plasma (PRP) injections to surgical release and decortication for lateral elbow tendinosis within a similar patient population.

Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation (Gautam 2015)
To evaluate the clinical and ultrasonographic changes in the morphology and vascularity of the common extensor tendon after injecting platelet-rich plasma (PRP) or corticosteroid (CS) for recalcitrant lateral epicondylitis (LE).

Platelet-rich plasma for chronic lateral epicondylitis: Is one injection sufficient? (Glanzmann 2015)
Chronic lateral epicondylitis is generally treated using nonsurgical methods including physiotherapy and infiltrations of cortisone or platelet-rich plasma (PRP).

A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis (Lebiedzinski A 2015)
The aim of the study was to assess the effectiveness of treating lateral epicondylitis (LE) with autologous conditioned plasma (ACP) and betamethasone injections, and to compare these methods over the course of a one year follow-up.

Platelet—Rich—Plasma Injections in Treating Lateral Epicondylosis: a Review of the Recent Evidence (Murray 2015) Platelet—rich—plasma injections from autologous blood have recently been used in centres worldwide for the treatment of tennis elbow.

Comparison of Local Injection of Platelet Rich Plasma and Corticosteroids in the Treatment of Lateral Epicondylitis of Humerus (Yadav 2015)
This study was conducted with an aim to compare the efficacy of PRP versus methyl-prednisolone local injection in patients with lateral epicondylitis.

Clinical Papers-PRP therapy for Knee Osteoarthritis

Intra-articular administration of peripheral blood stem cells with platelet-rich plasma regenerated articular cartilage and improved clinical outcomes for knee chondral lesions​ (Monckeberg 2019) Intra-articular peripheral blood stem cells with platelet-rich plasma regenerated articular cartilage and improved clinical outcomes for knee chondral lesions at five years of follow-up.
Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view This article intends to review the recent trends and advancing ideas for improvising PRP for us in early knee OA treatment
Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis
Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials

Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of Gonarthrosis (Cerza 2012)
To compare the clinical response of hyaluronic acid (HA) and platelet-rich plasma (PRP) treatment in 2 groups of patients affected by gonarthrosis.

Repeated Platelet Concentrate Injections Enhance Reparative Response of Microfractures in the Treatment of Chondral Defects of the Knee: An Experimental Study in an Animal Model (Milano 2012)
To assess the histology and biomechanics of repair cartilage after microfractures with and without repeated local injections of platelet concentrate for the treatment of full-thickness focal chondral defects of the knee.

A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis (Sanchez 2012) This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biological therapy for regenerative purposes, versus hyaluronic acid (HA) as a short-term treatment for knee pain from osteoarthritis.

Comparative Effectiveness of Platelet-Rich Plasma Injections for Treating Knee Joint Cartilage Degenerative Pathology: A Systematic Review and Meta-analysis (Chang 2013)
To explore the effectiveness of platelet-rich plasma (PRP) in treating cartilage degenerative pathology in knee joints.

Clinical outcomes of platelet rich plasma (PRP) as an adjunct to microfracture surgery in osteochondral lesions of the talus (Guney 2013)
To compare the effect of arthroscopic microfracture surgery alone or in combination with platelet rich plasma (PRP) on functional outcomes in osteochondral lesions of the talus.

Does platelet-rich plasma enhance microfracture treatment for chronic focal chondral defects? An in-vivo study performed in a rat model (Hapa Does 2013)
The purpose of the present study was to compare the effectiveness of platelet-rich plasma (PRP) + microfracture and microfracture treatments in the healing of chronic focal chondral defects.

Platelet‑rich plasma in patients with tibiofemoral cartilage degeneration (Hart 2013)
The objective of the present study was to determine if PRP can increase tibiofemoral cartilage regeneration and improve knee function.

The Efficacy of Platelet-Rich Plasma in the Treatment of Symptomatic Knee Osteoarthritis: A Systematic Review With Quantitative Synthesis (Koshbin 2013)
The purpose of this systematic review was to synthesize the available Level I and Level II literature on plateletrich plasma (PRP) as a therapeutic intervention in the management of symptomatic knee osteoarthritis (OA).

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis (Patel 2013) Platelet-rich plasma (PRP) provides symptomatic relief in early osteoarthritis (OA) of the knee.

The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee (Gobbi 2014)
To assess the outcome of intra-articular plateletrich plasma (PRP) injections into the knee in patients with early stages of osteoarthritis (OA) and to determine whether cyclical dosing would affect the end result.

Comparison of short-term results of intraarticular platelet-rich plasma (PRP) and hyaluronic acid treatments in early-stage gonarthrosis patients (Guler 2014)
The present study aimed to compare short-term clinical outcomes between intraarticular platelet-rich plasma (PRP) and hyaluronic acid (HA) treatments in early-stage gonarthrosis patients.

A Comparison between Platelet-Rich Plasma (PRP) and Hyaluronate Acid on the Healing of Cartilage Defects
The purpose of the study was to compare the therapeutic effects of P-PRP and HA on osteoarthritis in rabbit knees.
Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results, Abate 2015) Aim of this paper was to evaluate the efficacy of this association and to compare retrospectively these results with those of a cohort of patients treated with platelet-rich plasma only.

Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial (Duif 2015)
We aimed to identify the effects of intraoperative applied leukocyte-poor platelet-rich plasma (LPPRP) during knee arthroscopy for degenerative lesions involving pain, function and quality of life.

Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double‑blind, placebo‑controlled trial (Görmeli 2015)
To compare the effectiveness of intraarticular (IA) multiple and single platelet-rich plasma (PRP) injections as well as hyaluronic acid (HA) injections in different stages of osteoarthritis (OA) of the knee.

Short‑term outcomes of platelet‑rich plasma injection for treatment of osteoarthritis of the knee (Kanchanatawan 2015)
To compare the clinical outcomes of osteoarthritis indices (WOMAC and Lequesne scores) and adverse events in the treatment of osteoarthritis (OA) of the knee with platelet-rich plasma (PRP) versus hyaluronic acid (HA) or placebo.

Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review (Meheux 2015)
To determine (1) whether platelet-rich plasma (PRP) injection significantly improves validated patient-reported outcomes in patients with symptomatic knee osteoarthritis (OA) at 6 and 12 months postinjection, (2) differences in outcomes between PRP and corticosteroid injections or viscosupplementation or placebo injections at 6 and 12 months postinjection, and (3) similarities and differences in outcomes based on the PRP formulations used in the analyzed studies.

Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial, Raeissadat 2015)
Due to the high incidence of OA and its consequences, we decided to study the long-term effect of intra-articular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA.

Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials (Dai 2016)
To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for the treatment knee of osteoarthritis (OA).

Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis (Smith 2016) To determine the safety and efficacy of leukocyte-poor PRP autologous conditioned plasma (ACP) for knee OA treatment through a feasibility trial regulated by the US Food and Drug Administration (FDA).
Clinical Outcome of Bone Marrow Concentrate in Knee Osteoarthritis (Oliver 2015) This study evaluated the clinical efficacy of autologous intra-articular bone marrow concentrate with autologous lipoaspirate as a treatment option for osteoarthritis of the knee. Additionally, bone marrow concentrate samples from a patient population subset not necessarily enrolled in this study, but IRB approved, were sent for outside laboratory analysis.

Clinical Papers-PRP therapy for Plantar Fasciitis

Platelet-rich plasma injections for chronic plantar fasciitis (Martinelli 2012)
The purpose of this study was to assess the safety and preliminary clinical results of platelet-rich plasma (PRP) injections for treating chronic plantar fasciitis.

Comparison of Autologous Conditioned Plasma Injection, Extracorporeal Shockwave Therapy, and Conventional Treatment for Plantar Fasciitis: A Randomized Trial (Loonchew 2013)
To evaluate the efficacy of autologous conditioned plasma (ACP) compared to extracorporeal shockwave (ESWT) and conventional treatments for plantar fasciitis.

Platelet-Rich Plasma Efficacy Versus Corticosteroid Injection Treatment for Chronic Severe Plantar Fasciitis (Monto 2014)
Chronic plantar fasciitis is a common orthopedic condition that can prove difficult to successfully treat. In this study, autologous platelet-rich plasma (PRP), a concentrated bioactive blood component rich in cytokines and growth factors, was compared to traditional cortisone injection in the treatment of chronic cases of plantar fasciitis resistant to traditional nonoperative management.

A study to compare the efficacy of corticosteroid therapy with platelet-rich plasma therapy in recalcitrant plantar fasciitis: A preliminary report (Shetty 2014)
There are a number of modalities available to treat this condition, of which corticosteroid injection is, perhaps, the most popular.

Comparative effectiveness of autologous blood-derived products, shock-wave therapy and corticosteroids for treatment of plantar fasciitis: a network meta-analysis (Hsiao 2015)
To compare the efficacy of autologous blood-derived products (ABPs), CSs and shock-wave (SW) therapy in the treatment of plantar fasciitis.

Platelet rich plasma versus corticosteroid injection for plantarfasciitis: A comparative study (Jain 2015)
Intractable plantar fasciitis can be a difficult condition to treat. Early results of platelet richplasma (PRP) injection have been promising.

Comparison of platelet-rich plasma and steroid injection in the treatment of plantar fasciitis (Say 2015)
The aim of this study was to compare the effects of platelet-rich plasma (PRP) and steroid injections in patients diagnosed with plantar fasciitis.

Platelet-Rich-Plasma injection seems to be effective in treatment of plantar fasciitis : a case series (Vanegmond 2015)
The purpose of this study was to determine if a single platelet-rich-plasma injection at the origin of the plantar fascia in patients with plantar fasciitis gives a functional improvement.

Clinical Papers-PRP therapy for Muscle Injuries

Use of Autologous Platelet-rich Plasma to Treat Muscle Strain Injuries (Hammond 2009)
Standard nonoperative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery.

Ultrasound guided injections of Platelets Rich Plasma for muscle injury in professional athletes. Comparative study (Bubnov 2013)
Professional athletes require faster recovery after trauma. The aim of our study was to evaluate the efficacy of ultrasound guided platelets rich plasma (PRP) treatment for acute muscle injury comparing with traditional conservative therapy.

Rehabilitation of a partially torn distal triceps tendon after platelet rich plasma injection: a case report (Cheatham 2013)
Platelet Rich Plasma (PRP) is an emerging non-surgical intervention used for the treatment of tendon and ligament pathology.

Platelet-rich Plasma as an Effective Treatment for Proximal Hamstring Injuries (Wetzel 2013)
Proximal hamstring injuries can be disabling, and several traditional conservative treatments, including physiotherapy and nonsteroidal anti-inflammatory drugs, have been inconsistent.

Platelet-rich plasma treatment improves outcomes for chronic proximal hamstring injuries in an athletic population (Fader 2014)
Chronic proximal hamstring tendino – pathies is a disabling activity related condition. Currently, there is no well-accepted or extensively documented non-operative treatment option that provides consistently successful results.

Platelet-Rich Plasma Injections for the Treatment of Hamstring Injuries: A Randomized Controlled Trial (Hamid 2014)
A hamstring injury is one of the most common types of injury affecting athletes. Despite this, the optimal management of hamstring muscle injuries is not yet defined. The effect of autologous platelet-rich plasma (PRP) therapy on the recovery of hamstring injuries is unclear.

Clinical Papers-PRP Basic Research

Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients (Anitua 2007)
Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. Our aim was to examine the effect of a platelet-derived preparation rich in growth factors (PRGFs) in OA synovial cell biology.

Basic Science: Molecular and Biological Aspects of Platelet-Rich Plasma Therapies
Knowledge of the basic biological mechanisms involved in tissue response to injury should inform management of healing.

Platelet-Rich Plasma Differs According to Preparation Method and Human Variability (Mazzocca 2012)
Varying concentrations of blood components in platelet-rich plasma preparations may contribute to the variable results seen in recently published clinical studies.

The Positive Effects of Different Platelet-Rich Plasma Methods on Human Muscle, Bone, and Tendon Cells (Mazzocca 2012)
Clinical application of platelet-rich plasma (PRP) in the realm of orthopaedic sports medicine has yielded variable results. Differences in separation methods and variability of the individual may contribute to these variable results.

The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich
Plasma in Osteoarthritis (Sundman 2013)

Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patientreported pain and function scores.

The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes (Braun 2014)
The effect of platelet-rich plasma (PRP) on chondrocytes has been studied in cell and tissue culture, but considerably less attention has been given to the effect of PRP on synoviocytes.

Stimulation of the Superficial Zone Protein and Lubrication in the Articular Cartilage by Human Platelet-Rich Plasma (Sakata 2015)
Platelet-rich plasma (PRP) contains high concentrations of autologous growth factors that originate from platelets. Intra-articular injections of PRP have the potential to ameliorate the symptoms of osteoarthritis in the knee.

Platelet-rich plasma in orthopedics: State of the Art (Enneper 2016)
Platelet-rich plasma (PRP) concentrates have become increasingly important in recent years in the treatment of disorders of the locomotor system.

Clinical Papers-PRP therapy for Rotator Cuff

The effect of subacromial injections of autologous conditioned plasma versus cortisone for the treatment of symptomatic partial rotator cuff tears
Intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) represent efficacious medical treatments for osteoarthritis (OA), although no comparative study on long-term efficacy in hip OA exists.
Platelet-Rich Plasma Augmentation of Arthroscopic Hip Surgery for Femoroacetabular Impingement: A Prospective Study With 24-Month Follow-Up
The objective of this study is to evaluate the clinical and immunologic effects of intra-articular doses of plateletrich plasma (PRP) in arthroscopic hip surgery for femoroacetabular impingement.
Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis
The effectiveness of intra-articular platelet-rich plasma (PRP) injections has been evaluated in knee chondroplasty and osteoarthritis (OA); however, little evidence of its efficacy in hip OA exists.

Clinical Papers-PRP therapy for Jumpers Knee

Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections
Platelet-rich-plasma is increasingly used in chronic patellar tendinopathy. Ideal number of PRP injections needed is not yet established. This study compares the clinical outcomes of a single versus two consecutive PRP injections.
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy
Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-𝛽 (TGF-𝛽), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF)
Platelet-rich plasma injections for the treatment of refractory Achilles tendinopathy: results at 4 years
Chronic Achilles tendinopathy is responsible for a severe reduction in physical performance and persistent pain. There is currently a number of therapeutic options and the local administration of growth factors is an emerging treatment strategy.
Are Multiple Platelet-Rich Plasma Injections Useful for Treatment of Chronic Patellar Tendinopathy in Athletes?
To evaluate clinical and radiological outcomes of 3 consecutive ultrasound (US)–guided PRP injections for the treatment of chronic PT in athletes.
Use of Platelet-Rich Plasma for the Treatment of Refractory Jumper’s Knee
The aim of this study was to evaluate the efficacy of multiple platelet-rich palsma (PRP) injections on the healing of chronic refractory patellar tendinopathy after previous classical treatments have failed.

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