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Clinical Evidence Lipogems

Lipogems® is a new and innovative treatment that has helped over 35,000 patients worldwide. It has been extensively researched, please see some of the key clinical papers below for more information. To see how the treatment could help you make an appointment our multidisciplinary team or call 0330 2233332 for more information.

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Dr. Konrad Slynarski speaks to the Regenerative Clinic about his extensive experience using micro-fragmented adipose tissue stem cells in joint preservation and three year clinical studies in the field.


Vincenzo Condello incredible results show that the future of Orthobiologics has the potential to become a first-line treatment in sport medicine and joint preservation.

Clinical Papers Lipogems

Lipogems® A Miniature Literature Review (The Regenerative Clinic 2019) Regenerative medicine is an interdisciplinary field that seeks to develop the science and tools that can help repair or replace damaged or diseased human cells or tissues to restore normal function. It holds the promise of revolutionising the treatment of many conditions in the 21st century. Read full brochure.

Treatment of osteoarthritis with autologous and micro-fragmented adipose tissue (Blønd 2019)
Prof. Wilson (the Regenerative Clinic) “This is a great paper from my good friend Lars Blønd who is a consultant based in Denmark who is interested like me in regenerative treatments and joint preservation surgery. This is an excellent paper showing positive outcomes for Lipogems in the treatment of osteoarthritis at 12 months. Fundamentally it says it’s safe and also there are significant improvement in all of the schools that are routinely measured to assess outcome from these types of treatments.”
Read full article.

Long term efficacy of Micro-fragmented adipose tissue in the treatment of Knee Osteoarthritis (McGuire 2019) 
Intra-articular injection of Micro-fragmented adipose tissue (MAT) is a minimally invasive technique that has shown promising results for improving function and reducing pain in patients suffering with arthritis. Current treatments, including joint replacement, carry huge risk and if performed in those under the age of 55 are likely to produce poorer outcomes and require revision surgery. The aim of the study was to evaluate the clinical outcomes of patients with knee osteoarthritis (KOA) at 1-year following MAT treatment. Read full article.

Six month VAS and OHS Results of Patients treated with Lipogem® Treatment at The Regenerative Clinic UK (Heidari 2019)
At The Regenerative Clinic, we have treated 26 hip joints, which now are six months following Lipogem® treatment. The data gathered and analysed here is for this group. We have assessed patients’ responses at 3 months and 6 months following their treatment. Our findings show that 17 out of 26 patients have had a dramatic response of up to 83% reduction in pain, while just 9 have not responded; this means that 66% of our hip patients have seen an improvement in their functional outcomes and in their pain scores. Read full article.

Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results (Dall’Oca 2019)
MSC Lipogems® is a fairly easy technique. No adverse effects were recorded in our experience. Preliminary results showed a positive outcome according to all the grading systems used in this study even though a longer follow up is needed to validate this technique. Read full article.

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue (Nava 2019) We conclude that human micro-fragmented adipose tissue is an effective preparation with a long-lasting anti-inflammatory activity probably mediated by a long-term survival of their MSC (mesenchymal stem cell) content that releases a combination of cytokines that affect several mechanisms involved in inflammation processes. Read full article.
Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences (Lopa 2018) Osteoarthritis (OA) represents a relevant social and economic burden worldwide. “Mesenchymal stem cells” or, as recently proposed, “medicinal signaling cells” (MSCs) have been recently introduced as injective treatments for OA with the aim of restoring joint homeostasis. The aim of this review is to provide the reader with the tools necessary to interpret the currently available clinical data, focusing on the MSC mechanisms of action which might help to clarify what we should expect from this treatment. Read full article.

Autologous micro-fragmented adipose tissue for the treatment of diffuse
degenerative knee osteoarthritis: an update at 3 year follow-up (Russo 2018)

Our results point to autologous (obtained from the same individual) and micro-fragmented adipose tissue injection as an innovative and safe approach for the management of diffuse degenerative knee chondropathy in the mid-term. The procedure is simple, affordable, minimally invasive, and compliant with the regulatory panorama. Read full article.

Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis (Cattaneo 2018)
The result of the study pointed to micro-fragmented adipose tissue as a safe and beneficial adjuvant in the surgical treatment of degenerative knee chondropathy. The procedure is simple, sustainable, quick, minimally invasive, one-step, and safe. After one year, the results are very satisfactory and promising. A longer follow-up is needed to draw definitive conclusions and enlarge the indications. Read full article.

Safety and Efficacy of Percutaneous Injection of Lipogems® Micro-Fractured Adipose Tissue for Osteoarthritic Knee (Panchal 2018) The injection of autologous, micro-fractured, minimally manipulated adipose tissue appears to be a safe and effective treatment option for patients with refractory, severe (grade 3 or 4) knee OA. This study demonstrated significant improvements in pain, quality of life, and function for at least 12 months in this study population. This intervention may represent a nonsurgical treatment option to avoid knee joint replacement in this population; however, further investigation is needed. Read full article.
Refractory shoulder pain with osteoarthritis, and rotator cuff tear, treated with micro-fragmented adipose tissue (Striano 2018) The results from this study demonstrate significant improvements in shoulder pain, function and quality of life as represented by positive outcomes in all measured scores through twelve months. Read full article.
Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus (D’Ambrosi 2018) All patients reported clinical improvement six months after surgery with no reported complications. Functional scores at the latest follow-up are encouraging and confirm that the technique provides reliable pain relief and improvements in patients with osteochondral lesion of the talus. Read full article.

Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a sub-population with greater response (Panni 2018)
The knee injection of adipose-derived stem cells associated to arthroscopic debridement increased significantly the clinical and functional scores in patients with early knee osteoarthritis at a mid-term follow-up, especially those with higher pre-operative visual analogue (VAS) scores. Read full article.

Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes (Zeira 2018) This study evaluates the safety, feasibility, and clinical efficacy of using autologous and microfragmented adipose tissue for the treatment of spontaneous osteoarthritis in dogs. The procedure is simple, time sparing, cost-effective, minimally invasive, one-step, and eliminates the need for complex and time intensive cell culture processing. The lack of any complications and the long lasting successful results are of considerable importance for the use in human medicine. Read full article.
Microfragmented adipose injections in the treatment of knee osteoarthritis (Malanga 2018) Mesenchymal stem cells (MSCs) are multipotent adult stem cells that self-renew and have the ability to differentiate into various cell types, such as muscle, bone, and cartilage. These cells can be obtained from a patient and subsequently injected into a site of interest in the same patient (ie, autologous use). MSCs also demonstrate paracrine activity by releasing various growth factors and exhibit immunomodulatory capability. Read full article.

Autologous, micronized, and minimally manipulated adipose tissue resulted in significant improvement in pain, function and quality of life. No adverse events were reported (Striano 2017)
Autologous, micronized, and minimally manipulated adipose tissue resulted in significant improvement in pain, function and quality of life. No adverse events were reported.. Read full article.

Autologous Fat Transfer for Thumb Carpometacarpal Joint Osteoarthritis: A Prospective Study (Herold 2017)
Autologous fat transplantation is an appealing alternative, especially in early-stage basal joint osteoarthritis of the thumb. The low invasiveness of the procedure and early recovery of patients compared with classical procedures such as trapeziectomy, and the superior long-term results compared with classical injection therapy, make this approach feasible as a first-line therapy in early-stage basal joint osteoarthritis of the thumb. Read full article.

Dr Morrison First Year Experience with Lipogems
First Year Experience with Lipogems

Allogeneic Mesenchymal Stem Cells and Recycled Autologous Chondrons Mixed in a One-Stage Cartilage Cell Transplantion (Windt 2017)
This first-in-man trial supports a paradigm shift in which mesenchymal stem cells are applied as augmentations or “signaling cells” rather than differentiating stem cells and opens doors for other applications. Read full article.

Arthroscopic treatment of chondral defects in the hip including microfragmented adipose tissue transplantation (Jannelli 2017)
Articular cartilage possesses only a weak capacity for repair; on the other hand, mesenchymal stem cells (MSCs) are specified as appropriate cell candidates for regenerating incurable defects of articular cartilage due to the following characteristics: inherent chondrogenic property, easy availability, cell homing potential and immunomodulatory function.

Besides bone marrow, multiple tissues have been reported to contain MSCs. These include adipose tissue, unlike bone marrow, adipose tissue derived MSCs can be isolated in large quantities with minimal morbidity and discomfort. Read full article. 

Mesenchymal Stem Cells and Regenerative Medicine: How Lipogems® Technology Make Them Easy, Safe and More Effective to Use (Tremolada 2017)
Lipogems® was designed to harvest, process and inject aspirated fat tissue which is washed, emulsified and rinsed, while adipose cluster dimensions are gradually reduced in a completely closed device by only mechanical forces. Lipogems® tissue product represents a natural implantable bioreactor that incorporates the main elements for a perfect natural regenerative response: the Scaffold (the adipose tissue structure), the Cells (Pericytes/MSCs), and the Grow factors (secreted cytokines and chemokines). Read full article.

The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis (Hudetz 2017)
The results of our study indicate that the use of autologous and microfragmented adipose tissue in patients with knee OA (measured by dGEMRIC MRI) increased glycosaminoglycan (GAG) content in hyaline cartilage, which is in line with observed VAS and clinical results. Read full article.

Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis (Russo 2017)
The results of this study show the safety and feasibility of using autologous and micro-fragmented adipose tissue in patients affected by diffuse degenerative chondral lesions. The technique is safe, minimally invasive, simple, one-step, with low percentage of complications, and compliant with the regulatory panorama. Read full article.

Mesenchymal Stem Cells Use In Hip Arthroscopy: Medium Term Results In Case-Control Study (Bajwa 2016)
Treatment of chondral defects with MSCs appears to offer safe and effective treatment and results are better sustained than the microfracture control group. Conversion to hip arthroplasty risk appears to decrease with MSC treatment in medium-term. Read full article.

Lipogems® Product Treatment Increases the Proliferation Rate of Human Tendon Stem Cells without Affecting Their Stemness and Differentiation Capability (Randelli 2016)
This study supports that directly activating human tendon stem cells with the Lipogems® lipoaspirate could represent a new practical therapeutic approach. In fact, obtaining a lipoaspirate is easier, safer, and more cost-effective than harvesting cells from tendon or bone marrow biopsies, expanding them in Good Manufacturing Practice facility and then re-injecting them in the patient. Read full article.

Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development (Tremolada Overview and Science 2016) Lipogems® technology is emerging as a valid intraoperative system to obtain an optimal final product that may be used immediately for regenerative purposes. Read full article.
Injection of autologous micro-fragmented adipose tissue for the treatment of post-traumatic degenerative lesion of knee cartilage: a case report (Franceschini 2016) Although this is a single case report, our resultssuggest that the autologous, micro-fragmented and minimally manipulated adipose tissue injected in a joint affected by a chondral lesion provides support and potential healing, improves joint functionality and determines pain relief. Read full article.

Human Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects – In vitro (Bosetti 2015)
Research on mesenchymal stem cells from adipose tissue shows promising results for cell-based therapy in cartilage lesions. Read full article.

Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow (Zuk 2003)
Adipose tissue is an abundant and easily procured source of processes lipoaspirate cells, which have a potential like mesenchymal stem cells for use in tissue-engineering applications and as gene delivery vehicles. Read full article.

Human Adipose Tissue Is a Source of Multipotent Stem Cells (Zuk 2002) Adipose tissue is an abundant and easily procured source of processes lipoaspirate cells, which have a potential like mesenchymal stem cells for use in tissue-engineering applications and as gene delivery vehicles. Read full article.

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