Comparative Effectiveness of Platelet-Rich Plasma Injections for Treating Knee Joint Cartilage Degenerative Pathology: A Systematic Review and Meta-analysis

Author: Chang et al
Year: 2013

Abstract
Objectives:

To explore the effectiveness of platelet-rich plasma (PRP) in treating cartilage degenerative pathology in knee joints.

Data Sources:

Electronic databases, including PubMed and Scopus, were searched from the earliest record to September 2013.

Study Selection:

We included single-arm prospective studies, quasi-experimental, and randomized controlled trials that employed PRP to treat knee chondral degenerative lesions. Eight single-arm studies, 3 quasi-experimental, and 5 randomized controlled trials were identified, comprising 1543 participants.

Data Extraction:

We determined effect sizes for the selected studies by extracting changes in functional scales following the interventions and compared the PRP group pooled values with the pre-treatment baseline and the groups receiving placebo or hyaluronic acid (HA) injections.

Data Synthesis:

PRP injections in patients with knee degenerative pathology showed continual efficacy for 12 months compared with their pre-treatment condition. The effectiveness of PRP was likely better and more prolonged than HA. Injection doses equal to or less than 2, the use of a single-spinning approach, and lack of additional activators led to an uncertainty in the treatment effects. Patients with lower degrees of cartilage degeneration achieved superior outcomes as opposed to those affected by advanced osteoarthritis.

Conclusions:

PRP application improves function from basal evaluations in patients with knee joint cartilage degenerative pathology and tends to be more effective than HA administration. Discrepancy in the degenerative severity modifies the treatment responses, leading to participants with lower degrees of degeneration to benefit more from PRP injections.

 

https://www.ncbi.nlm.nih.gov/pubmed/24291594

Get in touch

Find your clinic

We offer appointments nationwide and now working with partners abroad providing cutting edge Regenerative Medicine to patients in Dubai, Australia, Spain and Pakistan.

Sign-up to receive our recent news and the latest developments in regenerative medicine.

You can change your mind at any time by clicking the unsubscribe link in the footer of any email you receive from us, or by contacting us at info@theregenerativeclinic.co.uk. We will treat your information with respect. For more information about our privacy practices please visit our website. By clicking below, you agree that we may process your information in accordance with these terms.

We use Mailchimp as our marketing platform. By clicking below to subscribe, you acknowledge that your information will be transferred to Mailchimp for processing. Learn more about Mailchimp's privacy practices here.