fbpx

Long term efficacy of Micro-fragmented adipose tissue in the treatment of Knee Osteoarthritis

Author: McGuire et al
Year: 2019

Purpose
Intra-articular injection of Micro-fragmented adipose tissue (MAT) is a minimally invasive technique that has shown promising results for improving function and reducing pain in patients suffering with arthritis. Current treatments, including joint replacement, carry huge risk and if performed in those under the age of 55 are likely to produce poorer outcomes and require revision surgery. The aim of the study was to evaluate the clinical outcomes of patients with knee osteoarthritis (KOA) at 1-year following MAT treatment.

Materials and methods
Pre-op: patients with KOA were x-rayed to assess severity and scored using VAS and OKS. All patients with measures of VAS >5 and OKS <30 were included in the study (n=84). Procedure: autologous adipose tissue was aspirated from each patient under sedation administered by an anaesthetist, and micro-fragmented using the Lipogems® system. The MAT was then injected, using ultrasound guidance, into the affected joint. Post-op: at 3, 6 and 12 months, patients VAS and OKS measures were re-scored and evaluated.

Results
A significant change was recorded comparing pre- and post-operative outcome measures. VAS scores saw improvement (p<0.001) from a mean value of 6.86±1.48, at 3 (3.71±2.67), 6 (3.67±2.82), and 12 months (3.54±3.12). OKS saw improvement (p<0.001) from a mean value of 21.2±5.66, at 3 (31.3±9.64), 6 (29.7±10.3), and 12 months (30.9±8.16). Positive responses for VAS and OKS were observed for >75% of patients at 3 and 6 months, and >80% for those who have reached the 12-month follow-up.

Conclusion
The study demonstrates a significant improvement 1-year following MAT treatment for patients suffering KOA. Most patients experienced reduced pain and increased functionality. Paired with the minimally invasive approach, MAT looks to be an ideal interim treatment for joint arthritis that can delay the need for arthroplasty, preserving the native joint and delaying replacement. Further studies are required to identify the point at which efficacy may be lost.

Get in touch

Find your clinic

We offer appointments nationwide and now working with partners abroad providing cutting edge Regenerative Medicine to patients in Dubai, Australia, Spain and Pakistan.

Sign-up to receive our recent news and the latest developments in regenerative medicine.

You can change your mind at any time by clicking the unsubscribe link in the footer of any email you receive from us, or by contacting us at info@theregenerativeclinic.co.uk. We will treat your information with respect. For more information about our privacy practices please visit our website. By clicking below, you agree that we may process your information in accordance with these terms.

We use Mailchimp as our marketing platform. By clicking below to subscribe, you acknowledge that your information will be transferred to Mailchimp for processing. Learn more about Mailchimp's privacy practices here.