Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up

Author: Pettine et al
Year: 2017

The Regenerative Clinic's view on this research

Mr Ali Noorani “There have been three studies published for the use of bone marrow aspirate concentrate (BMAC) for discogenic back pain in the lumbar area.  The three papers were published by the same group in 2014, 2016, 2017.  They interestingly show the results of the same group of patients followed up at 12 months, 2 year and 3 year follow up. The paper published 2017 had a total number of 26 patients, all of which were surgical consults. These are all surgical candidates and the injections were put forward as an alternative to surgery with a 3 year follow up with the same patients. They found out that over 2000 CFU/ml (i.e. cell number) had faster and better clinical outcomes. The average pain reduction was 70% and approximately 80% have still not had surgery at 3 years, therefore they were successful in avoiding this. The study also concluded there were no adverse events related to bone marrow aspiration or injection and the study provides evidence of safety as well as good feasibility of intradiscal BMAC therapy.”


Purpose: The purpose of this study is to assess safety and feasibility of intradiscal bone marrow concentrate (BMC) injections to treat low back discogenic pain as an alternative to surgery with three year minimum follow-up.

Methods: A total of 26 patients suffering from degenerative disc disease and candidates for spinal fusion or total disc replacement surgery were injected with 2 ml autologous BMC into the nucleus pulposus of treated lumbar discs. A sample aliquot of BMC was characterized by flow cytometry and CFU-F assay to determine progenitor cell content. Improvement in pain and disability scores and 12 month post-injection MRI were compared to patient demographics and BMC cellularity.

Results: After 36 months, only six patients progressed to surgery. The remaining 20 patients reported average ODI and VAS improvements from 56.7 ± 3.6 and 82.1 ± 2.6 at baseline to 17.5 ± 3.2 and 21.9 ± 4.4 after 36 months, respectively. One year MRI indicated 40% of patients improved one modified Pfirrmann grade and no patient worsened radiographically. Cellular analysis showed an average of 121 million total nucleated cells per ml, average CFU-F of 2713 per ml, and average CD34+ of 1.82 million per ml in the BMC. Patients with greater concentrations of CFU-F (>2000 per ml) and CD34+ cells (>2 million per ml) in BMC tended to have significantly better clinical improvement.

Conclusions: There were no adverse events related to marrow aspiration or injection, and this study provides evidence of safety and feasibility of intradiscal BMC therapy. Patient improvement and satisfaction with this surgical alternative supports further study of the therapy.


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